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TXNIP Switches Tracks toward a Terminal UPR

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Presentation on theme: "TXNIP Switches Tracks toward a Terminal UPR"— Presentation transcript:

1 TXNIP Switches Tracks toward a Terminal UPR
Tracy G. Anthony, Ronald C. Wek  Cell Metabolism  Volume 16, Issue 2, Pages (August 2012) DOI: /j.cmet Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 TXNIP Serves as the Wye Switch that Redirects β Cell Cell Fate from an Adaptive to Terminal UPR β cells can encounter physiological conditions leading to low remediable ER stress (blue) or hyperactivated ER stress that is irremediable (red). These stress signals are recognized by ER-resident proteins IRE1α and PERK, which signal elevated expression of TXNIP. Elevated TXNIP levels during hyperactivated stress directs the wye switch for cell fate, leading to a terminal UPR, featuring activation of the inflammasome and pyroptosis. Cell Metabolism  , DOI: ( /j.cmet ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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