Presentation is loading. Please wait.

Presentation is loading. Please wait.

Elevated levels of gremlin-1 in eutopic endometrium and peripheral serum in patients with endometriosis  Guihua Sha, Ph.D., Yan Zhang, M.D., Chengyan.

Published by주일 기 Modified over 5 years ago

Similar presentations

Presentation on theme: "Elevated levels of gremlin-1 in eutopic endometrium and peripheral serum in patients with endometriosis  Guihua Sha, Ph.D., Yan Zhang, M.D., Chengyan."— Presentation transcript:

1 Elevated levels of gremlin-1 in eutopic endometrium and peripheral serum in patients with endometriosis  Guihua Sha, Ph.D., Yan Zhang, M.D., Chengyan Zhang, M.D., Yuping Wan, M.D., Zhengmiao Zhao, B.S., Chunyan Li, M.D., Jinghe Lang, M.D.  Fertility and Sterility  Volume 91, Issue 2, Pages (February 2009) DOI: /j.fertnstert Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 (A) Negative control for GREM1 (red, A1), CD146 (green, A2), and nucleus staining with 6-diamino-2-phenylindole (DAPI) (blue, A3), as well as the overlapped three-color image (A4). (B) The corresponding image for GREM1 (B1), CD146 (B2), and nucleus staining (B3), as well as the overlapped three-color image (B4). Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 (A) With the recombinant mouse standard reference, a band of the expected 20 kDa was obtained. (B) When the difference between cancerous lung tissue and paraneoplastic lung tissue was compared, the same bands of about 47 and 60 kDa were gained as from endometrium. Ab = antibody. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

4 Figure 3 The difference in GREM1 protein expression between endometriotic and nonendometriotic eutopic endometria. EM = endometriosis; Ab = antibody. The difference is statistically significant, P<.05. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

5 Figure 4 Standard curve with mouse recombinant standard reference of GREM1 used to measure the concentration of GREM1 in peripheral serum. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

6 Figure 5 Serum concentration of GREM1 by menstrual phase. P = proliferative phase; S = secretory phase; EM = endometriosis. ∗Statistically significant difference between the two groups, P=.037; the differences in comparisons of other sample groups did not reach statistical significance. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Download ppt "Elevated levels of gremlin-1 in eutopic endometrium and peripheral serum in patients with endometriosis  Guihua Sha, Ph.D., Yan Zhang, M.D., Chengyan."

Similar presentations

Molecular characterization of uterine fibroids and its implication for underlying mechanisms of pathogenesis  Paul J. Hoffman, B.S., Dawn B. Milliken,

Molecular characterization of uterine fibroids and its implication for underlying mechanisms of pathogenesis  Paul J. Hoffman, B.S., Dawn B. Milliken,
What’s the delay? A qualitative study of women’s experiences of reaching a diagnosis of endometriosis  Karen Ballard, Ph.D., Karen Lowton, Ph.D., Jeremy.

What’s the delay? A qualitative study of women’s experiences of reaching a diagnosis of endometriosis  Karen Ballard, Ph.D., Karen Lowton, Ph.D., Jeremy.
TAGLN expression is deregulated in endometriosis and may be involved in cell invasion, migration, and differentiation  Gabriela dos Santos Hidalgo, M.Sc.,

TAGLN expression is deregulated in endometriosis and may be involved in cell invasion, migration, and differentiation  Gabriela dos Santos Hidalgo, M.Sc.,
Sphingosine pathway deregulation in endometriotic tissues

Sphingosine pathway deregulation in endometriotic tissues
Use of proteomic analysis of endometriosis to identify different protein expression in patients with endometriosis versus normal controls  Hong Zhang,

Use of proteomic analysis of endometriosis to identify different protein expression in patients with endometriosis versus normal controls  Hong Zhang,
The endometria of patients with endometriosis show higher expression of class I human leukocyte antigen than the endometria of healthy women  María del.

The endometria of patients with endometriosis show higher expression of class I human leukocyte antigen than the endometria of healthy women  María del.
Anca Chelariu-Raicu, M. D. , Cornelia Wilke, Ph. D. , Melanie Brand, M

Anca Chelariu-Raicu, M. D. , Cornelia Wilke, Ph. D. , Melanie Brand, M
Genome-based expression profiling as a single standardized microarray platform for the diagnosis of endometrial disorder: an array of 126-gene model 

Genome-based expression profiling as a single standardized microarray platform for the diagnosis of endometrial disorder: an array of 126-gene model 
Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients 

Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients 
Anton Langebrekke, M.D., Erik Qvigstad, M.D., Ph.D. 

Anton Langebrekke, M.D., Erik Qvigstad, M.D., Ph.D. 
Local injury to the endometrium in controlled ovarian hyperstimulation cycles improves implantation rates  Liang Zhou, M.D., Rong Li, M.D., Ph.D., Rong.

Local injury to the endometrium in controlled ovarian hyperstimulation cycles improves implantation rates  Liang Zhou, M.D., Rong Li, M.D., Ph.D., Rong.
Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients  Hong-Yuan.

Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients  Hong-Yuan.
Human leukocyte antigen-G, a ligand for the natural killer receptor KIR2DL4, is expressed by eutopic endometrium only in the menstrual phase  Masaaki.

Human leukocyte antigen-G, a ligand for the natural killer receptor KIR2DL4, is expressed by eutopic endometrium only in the menstrual phase  Masaaki.
Michael M. Alper, M.D.  Fertility and Sterility 

Michael M. Alper, M.D.  Fertility and Sterility 
Lymph node involvement and lymphovascular invasion in deep infiltrating rectosigmoid endometriosis  Jean-Christophe Noël, M.D., Charles Chapron, M.D.,

Lymph node involvement and lymphovascular invasion in deep infiltrating rectosigmoid endometriosis  Jean-Christophe Noël, M.D., Charles Chapron, M.D.,
Sébastien Colette, Ph. D. , Sylvie Defrère, Ph. D

Sébastien Colette, Ph. D. , Sylvie Defrère, Ph. D
TAGLN expression is deregulated in endometriosis and may be involved in cell invasion, migration, and differentiation  Gabriela dos Santos Hidalgo, M.Sc.,

TAGLN expression is deregulated in endometriosis and may be involved in cell invasion, migration, and differentiation  Gabriela dos Santos Hidalgo, M.Sc.,
Growth rates of ovarian follicles during natural menstrual cycles, oral contraception cycles, and ovarian stimulation cycles  Angela R. Baerwald, Ph.D.,

Growth rates of ovarian follicles during natural menstrual cycles, oral contraception cycles, and ovarian stimulation cycles  Angela R. Baerwald, Ph.D.,
Can an educational DVD improve the acceptability of elective single embryo transfer? A randomized controlled study  Nicole Hope, M.B., B.S., Hon., Luk.

Can an educational DVD improve the acceptability of elective single embryo transfer? A randomized controlled study  Nicole Hope, M.B., B.S., Hon., Luk.
Expression of motility-related molecule Cdc42 in endometrial tissue in women with adenomyosis and ovarian endometriomata  Gaia Goteri, M.D., Andrea Ciavattini,

Expression of motility-related molecule Cdc42 in endometrial tissue in women with adenomyosis and ovarian endometriomata  Gaia Goteri, M.D., Andrea Ciavattini,

Similar presentations

Ads by Google