1. Association of the GAA1013→GAG polymorphism of the insulin-like growth factor-1 receptor (IGF1R) gene with premature pubarche 
Maria Belen Roldan, M.D., Carlie White, B.S., Selma Feldman Witchel, M.D. 
Fertility and Sterility 
Volume 88, Issue 2, Pages (August 2007)
DOI: /j.fertnstert
Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

2. FIGURE 1
Potential outcomes after gonadarche for girls with premature pubarche. After presentation with premature pubarche caused by premature adrenarche, some girls have normal androgen concentrations and regular menses during their teen years. Post-gonadarche, some girls manifest persistent HA and may develop oligomenorrhea or amenorrhea; these are clinical features that are consistent with the development of PCOS. The presence of the G variant in the IGF1R gene may increase the propensity for a girl with PP to develop PCOS.
Roldan. IGF1R gene and premature pubarche. Fertil Steril 2007.
Fertility and Sterility  , DOI: ( /j.fertnstert )
Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions