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Delivering Three Punches to Knockout Intracellular Bacteria

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Presentation on theme: "Delivering Three Punches to Knockout Intracellular Bacteria"— Presentation transcript:

1 Delivering Three Punches to Knockout Intracellular Bacteria
Emilie Narni-Mancinelli, Eric Vivier  Cell  Volume 157, Issue 6, Pages (June 2014) DOI: /j.cell Copyright © 2014 Elsevier Inc. Terms and Conditions

2 Figure 1 A Two-Step Process for Targeting Intracytoplasmic Bacteria
Step 1. Perforin binds to the cell membrane and generates pores allowing the delivery of lytic granule content into the infected cell. Step 2. Granulysin penetrates the bacterial membrane to facilitate the entry of granzymes into intracytoplasmic bacteria. While granzymes can limit bacterial spreading by inducing apoptosis of infected cells, direct delivery of granzymes into bacteria mediated by granulysin eliminates bacteria independently of host cell death. Cell  , DOI: ( /j.cell ) Copyright © 2014 Elsevier Inc. Terms and Conditions

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