1. Anaphylaxis Journal of Allergy and Clinical Immunology
F. Estelle R. Simons, MD, FRCPC 
Journal of Allergy and Clinical Immunology 
Volume 125, Issue 2, Pages S161-S181 (February 2010)
DOI: /j.jaci
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2. Fig 1
Mechanisms underlying human anaphylaxis. Anaphylaxis is commonly mediated through an immune IgE-dependent mechanism. Rarely, it occurs through another immune mechanism. Uncommonly, it occurs through direct (nonimmune) activation of mast cells. Idiopathic anaphylaxis, currently a diagnosis of exclusion, presents opportunities for identification of previously unrecognized triggers, elucidation of pathophysiologic mechanisms, and identification of patients with mastocytosis or clonal mast cell disorders.69
Journal of Allergy and Clinical Immunology  , S161-S181DOI: ( /j.jaci )
Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions