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The LargPAD Trial: Phase IIA evaluation of l-arginine infusion in patients with peripheral arterial disease  Vikram S. Kashyap, MD, Ryan O. Lakin, MD,

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Presentation on theme: "The LargPAD Trial: Phase IIA evaluation of l-arginine infusion in patients with peripheral arterial disease  Vikram S. Kashyap, MD, Ryan O. Lakin, MD,"— Presentation transcript:

1 The LargPAD Trial: Phase IIA evaluation of l-arginine infusion in patients with peripheral arterial disease  Vikram S. Kashyap, MD, Ryan O. Lakin, MD, Patricia Campos, BSE, Matthew Allemang, MD, Ann Kim, MD, Timur P. Sarac, MD, Alfred Hausladen, PhD, Jonathan S. Stamler, MD  Journal of Vascular Surgery  Volume 66, Issue 1, Pages (July 2017) DOI: /j.jvs Copyright © 2017 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Vessel area changes showed augmented responses to l-arginine (l-arg) infusion at all doses of acetylcholine (Ach). Data are shown as the mean ± standard error of the mean (range bars). ***P < .01, ****P < .001 by two-way analysis of variance (ANOVA). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2017 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Percentage increase in limb volumetric flow (Q) to each dose of l-arginine (l-arg): 50 (n = 3), 100 (n = 10), and 500 mg (n = 9) infusion. The l-arg infusion led to a significant increase in Q. Data are shown as mean ± standard error of the mean (range bars). Ach, Acetylcholine. P < .005 by Fisher post hoc analysis. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2017 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Percentage increase in serum levels of l-arginine (l-arg) and metabolites after infusion of l-arg. Data are shown as mean ± standard error of the mean (range bars). *P < .05, **P < .005. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2017 Society for Vascular Surgery Terms and Conditions

5 Fig 4 Measured differences in nitric oxide (NO) metabolite levels (NOx) in venous and arterial blood samples before and after l-arginine (l-arg) infusion. Data are shown as the mean ± standard error of the mean (range bars). The P values are shown. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2017 Society for Vascular Surgery Terms and Conditions

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