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Yohei Hayashi, Ph. D. , Mitinori Saitou, M. D. , Ph. D

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1 Germline development from human pluripotent stem cells toward disease modeling of infertility 
Yohei Hayashi, Ph.D., Mitinori Saitou, M.D., Ph.D., Shinya Yamanaka, M.D., Ph.D.  Fertility and Sterility  Volume 97, Issue 6, Pages (June 2012) DOI: /j.fertnstert Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Schematic representations of human germline development revealed by in vivo and in vitro approaches. hEGC = human embryonic germ cell; hESC = human embryonic stem cell; PGC = primordial germ cell. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Schematic representations of possible strategies of in vitro disease modeling using hESCs/iPSCs. ESC = embryonic stem cell; hESC = human embryonic stem cell; iPSC = induced pluripotent stem cell; PGC = primordial germ cell; POF = premature ovarian failure; POI = primary ovarian insufficiency. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions


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