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Fig. 5 MTAP status remains nonpredictive of responsiveness to nutrient restriction in a panel of tissue-matched cell lines. MTAP status remains nonpredictive.

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Presentation on theme: "Fig. 5 MTAP status remains nonpredictive of responsiveness to nutrient restriction in a panel of tissue-matched cell lines. MTAP status remains nonpredictive."— Presentation transcript:

1 Fig. 5 MTAP status remains nonpredictive of responsiveness to nutrient restriction in a panel of tissue-matched cell lines. MTAP status remains nonpredictive of responsiveness to nutrient restriction in a panel of tissue-matched cell lines. (A) Western blot validation of MTAP expression. (B) Relative metabolite abundance of MTA in MTAP+/+ versus MTAP−/− cell lines. P values were obtained from Student’s t test. (C) Heat map of top 50 differential metabolites between MTAP+/+ and MTAP−/− cell lines. Top affected pathways are indicated. (D) PCA of variance between MTAP+/+ and MTAP−/− groups. (E to G) Relative metabolite abundance of (E) methionine, (F) cysteine, and (G) serine and the resulting heat maps of global metabolic profiles generated in each cell line from the indicated nutrient restriction. (H) Relative metabolite abundance of MTA in cell lines cultured in complete or methionine-restricted medium. (I) Fraction of significantly altered (P < 0.05, Student’s t test) metabolites that are related (i.e., within five reactions) or unrelated to methionine. (J) Assignment of PC that displays greatest variance between the indicated groups. Sydney M. Sanderson et al. Sci Adv 2019;5:eaav7769 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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