1. Voltage-gated K+ and Ca2+ channel currents remain normal in horizontal cells from Cx57-VGAT−/− retinae.
Voltage-gated K+ and Ca2+ channel currents remain normal in horizontal cells from Cx57-VGAT−/− retinae. A–H, Whole-cell voltage-clamp recordings from isolated horizontal cells from Cx57-tdTomato VGAT+/+ (A–D) and Cx57-VGAT−/− (E–H) mice show that the membrane currents of horizontal cells are unaffected by the deletion of VGAT. Examples of inward and outward K+ currents from normal (A) and VGAT knock-out (E) horizontal cells are similar, and their peak current–voltage (I–V) relations (B, F) are comparable. Ca channel currents recorded with 10 mm Ba2+ in wild-type (C) and knockout (G) are similar, with indistinguishable I–V relations (D, H).
Arlene A. Hirano et al. eNeuro 2016;3:ENEURO
©2016 by Society for Neuroscience