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Published byLionel Fortier Modified over 5 years ago
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Association of MMP expression with macrophages.
Association of MMP expression with macrophages. Hematoxylin-eosin (H&E), Ziehl-Neelsen (AFB), macrophage (CD11b+, red) and MMP-9 (brown) staining was performed on lung tissue sections from a representative M. tuberculosis-infected (H37Rv, 14 wpi, without TB treatment) mouse with a cavitary lesion (arrow). (A) Expression of MMP-9 was noted at the sites of infection and colocalized with infected areas and the CD11b+ signal. Higher-power views demonstrate CD11b+ and MMP-9 expression in the cellular rim surrounding cavities (B) and in the adjacent pneumonia (C). Numerous bacteria were noted in these lesions. Alvaro A. Ordonez et al. Dis. Model. Mech. 2016;9: © Published by The Company of Biologists Ltd
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