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Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung  Christina C. Lewis, PhD, Bruce Aronow, PhD, John Hutton, MD,

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Presentation on theme: "Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung  Christina C. Lewis, PhD, Bruce Aronow, PhD, John Hutton, MD,"— Presentation transcript:

1 Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung 
Christina C. Lewis, PhD, Bruce Aronow, PhD, John Hutton, MD, Joanna Santeliz, PhD, Krista Dienger, BS, Nancy Herman, BS, Fred D. Finkelman, MD, Marsha Wills-Karp, PhD  Journal of Allergy and Clinical Immunology  Volume 123, Issue 4, Pages e8 (April 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Gene expression changes in the lungs of allergen- and cytokine-treated mice. A, Hierarchic clustering of gene expression data from HDM or RWP allergen-exposed, rIL-4– and rIL-13–treated, and PBS-exposed BALB/c wild-type mice revealed that 426 genes were significantly different (P < .05) between the treatment and PBS control groups. Data shown are for 2 independent samples per treatment B, Venn analysis of gene expression changes showed that 23 genes were shared after all 3 exposures. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 A-H, Verification of IL-13–dependent gene expression changes by means of quantitative real-time PCR. Gene expression changes identified in microarray analyses were verified in the whole lungs of wild-type BALB/c mice treated with PBS or IL-13. ∗Genes significantly different (P < .05) from those in control animals. Journal of Allergy and Clinical Immunology  , e8DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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