1. The ND6P25L mtDNA mutation reduces gut microbiota diversity in C57BL/6J mice.
The ND6P25L mtDNA mutation reduces gut microbiota diversity in C57BL/6J mice. (A to C) 16S rRNA marker gene sequence analysis of microbiota in fecal samples from mice harboring the mtDNA ND6P25L on the C57BL/6J nuclear background. Shannon diversity index (A) data and medians ± interquartile ranges of 16 mice per group are from at least three independent breeding pairs per group. Data were analyzed using linear mixed-effects models. Principal coordinates analysis of (B) weighted UniFrac distance between samples from all experiments visualizing community amount differences between samples, where percent total variation captured by each axis is indicated. Ellipses represent the 80% confidence interval for samples in each group. The relative abundance of five major bacterial taxa (C) in mice with the indicated mtDNA with medians ± interquartile ranges are from all samples. *P < 0.05 and **P < 0.01 by linear mixed-effects models (A), PERMANOVA test (B), or generalized linear mixed-effects models (C).
Tal Yardeni et al., Sci. Signal. 2019;12:eaaw3159
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