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A signal transducer and activator of transcription 6 haplotype influences the regulation of serum IgE levels  Michaela Schedel, MSc, David Carr, BSc,

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Presentation on theme: "A signal transducer and activator of transcription 6 haplotype influences the regulation of serum IgE levels  Michaela Schedel, MSc, David Carr, BSc,"— Presentation transcript:

1 A signal transducer and activator of transcription 6 haplotype influences the regulation of serum IgE levels  Michaela Schedel, MSc, David Carr, BSc, Norman Klopp, PhD, Bernd Woitsch, MD, Thomas Illig, PhD, Daniel Stachel, MD, Irene Schmid, MD, Christian Fritzsch, MD, Stephan K. Weiland, MD, Erika von Mutius, MD, Michael Kabesch, MD  Journal of Allergy and Clinical Immunology  Volume 114, Issue 5, Pages (November 2004) DOI: /j.jaci Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Gene structure of STAT6 indicating the location of all SNPs genotyped for this study. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Odds ratios and 95% CIs for IgE percentiles (50th, 66th, and 90th percentile) by the STAT6 CGTGTT haplotype (as calculated by haplotype-trend regression model). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

4 Fig 3 Putative enhancer sequence located in intron 2 of the STAT6 gene in human and different primate sequences. The core sequence for NF-κB is presented in capital letters, the matrix in lower-case letters. Polymorphism C2892T changes the inner matrix of the NF-κB TFB (black box [c/t]). Differences between sequences of humans and primates are marked gray. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

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