1. Dancing with the Stars: Phenolic Glycolipids Partners with Macrophages
Micah D. Dunlap, Shabaana A. Khader 
Cell Host & Microbe 
Volume 22, Issue 3, Pages (September 2017)
DOI: /j.chom
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1
Mycobacterial PGLs Partner with Macrophages to Promote Nerve Demyelination
Tissue resident macrophages (Mɸs) phagocytose PGL-1 expressing Mycobacterium leprae (Mlep). PGL-mediated activation of the intracellular PAMP sensor STING induces CCL2 production, which recruits permissive CCR2-expressing monocytes to sustain infection. Infected and uninfected macrophages also leave the tissue and patrol nerve axons, where Mlep PGL-1 induces expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in infected macrophages. NO production by Mlep infected macrophages leads to mitochondrial damage and demyelination of neurons.
Cell Host & Microbe  , DOI: ( /j.chom )
Copyright © 2017 Elsevier Inc. Terms and Conditions