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New Research Findings on Clinical Benefits of Bisphosphonates in Patients With Advanced Prostate Cancer  Noel W. Clarke  European Urology Supplements 

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Presentation on theme: "New Research Findings on Clinical Benefits of Bisphosphonates in Patients With Advanced Prostate Cancer  Noel W. Clarke  European Urology Supplements "— Presentation transcript:

1 New Research Findings on Clinical Benefits of Bisphosphonates in Patients With Advanced Prostate Cancer  Noel W. Clarke  European Urology Supplements  Volume 5, Issue 17, Pages (October 2006) DOI: /j.eursup Copyright © 2006 European Association of Urology Terms and Conditions

2 Fig. 1 Treatment of prostate cancer metastases with bisphosphonates [7–13]. European Urology Supplements 2006 5, DOI: ( /j.eursup ) Copyright © 2006 European Association of Urology Terms and Conditions

3 Fig. 2 Zoledronic acid consistently reduces all types of SREs (24 mo). SRE=skeletal-related event; HCM=hypercalcaemia of malignancy. Data from Saad et al. [7]. European Urology Supplements 2006 5, DOI: ( /j.eursup ) Copyright © 2006 European Association of Urology Terms and Conditions

4 Fig. 3 Prostate cancer: multiple event analysis by study period [15]. SRE=skeletal-related event. Data from Saad et al. [7,11]. European Urology Supplements 2006 5, DOI: ( /j.eursup ) Copyright © 2006 European Association of Urology Terms and Conditions

5 Fig. 4 Prostate cancer: reduction of SRE risk by zoledronic acid, by SRE history. SRE=skeletal-related event. Data from Saad et al. [7]. European Urology Supplements 2006 5, DOI: ( /j.eursup ) Copyright © 2006 European Association of Urology Terms and Conditions

6 Fig. 5 Zoledronic acid has a greater efficacy (per primary end point) in patients with no pain at baseline. SRE=Skeletal-related event. Data from Eastham et al. [18]. European Urology Supplements 2006 5, DOI: ( /j.eursup ) Copyright © 2006 European Association of Urology Terms and Conditions

7 Fig. 6 Zoledronic acid for the prevention of bone metastases in patients with solid tumours. Adapted with permission from Mystakidou et al. [28]. European Urology Supplements 2006 5, DOI: ( /j.eursup ) Copyright © 2006 European Association of Urology Terms and Conditions


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