1. OvulonaTM monitors the end-organ effect of all reproductive effectors by measuring bioelectronic admittance of the outer-cervix tissue
OvulonaTM basic concept model
(NOT showing real features):
OvulonaTM monitors admittance of the exocervix, the outside of the end organ which integrates the effects of all key reproductive effectors. We call this FIVTM, or Folliculogenesis In VivoTM
Key to FIV™: Cervix uteri receives endocrinological and neurological signals controlling reproduction
Unlike other methods, FIVTM anticipates AND detects ovulation, and reflects processes that affect or are related to menstrual periodicity
FERTILE DAY 1
Posterior
Fornix
The woman inserts the Ovulona™ device much like a tampon with its tip extending to the Posterior Fornix. Planned modification will be a telemetric vaginal insert obviating daily insertion.

2. Hormone levels in blood circulation during menstrual cycle
Detecting the fertile window requires integration of all inputs into the system, received from the ovaries and from the brain
Hormone levels in blood circulation during menstrual cycle
Female Reproductive System
Ovary
Fallopian Tube
Uterus
Cervix
Vagina
fertile
window
Estrogen
Follicle-Stimulating Hormone
Luteinizing Hormone
Progesterone
The fertile window results from a complex interplay of multiple variables including signals from the brain, on which the ovary is “obligatorily dependent1,” sensitive to stress2 and affecting the timing and intensity of the mid-cycle LH surge3
Reproductive organs have a dense innervation and are under a local regulation of hormones, prostaglandins and other effectors
The cervix is central to experiencing the results of the interplay of all these variables
Monitoring the cervix yields information that circulating body-fluid hormones can’t provide
All commercial products track only a single circulating hormone (or two in one case), and do so indirectly
1 "The hypothalamic pulse generator: The reproductive core,” J. Hotchkiss and E. Knobil, Chapter 7 in Reproductive Endocrinology, Surgery, and Technology, (editors: Adashi, Rock, and Rosenwaks) Lippincott - Raven, (1)124 – 162, 1996
2 “Brain opioid peptides and menstrual cyclicity,” P.R. Gindoff and M. Ferin, Seminars in Reproductive Endocrinology 5(125), 1987
3 "The gonads: Development & function of the reproductive system,” W. F. Ganong, Review of Medical Physiology, 17th edition, Chapter 23, Appleton & Lange, 1995

3. From patients’ Ovulona™ units to a physician’s Ovulograph™
Friendly Technology
Ovulographic™ Folliculogenesis In Vivo™ (FIV™) screening concurrently cervical health
Data From Home To
Healthcare Providers
Test in Posterior Fornix
From patients’ Ovulona™ units to a physician’s Ovulograph™
– when needed
Next generation telemetric embodiment for users’ convenience
Folliculogenesis data
correlated with
auxiliary data (e.g. BBT)
Importance of the topic: The quality of ovulation is strained in normal women - by Richard S. Legro, Human Reproduction, Vol.28, No.6 pp. 1446–1447, 2013
‘Improve the methods and criteria used to assess ovulatory dysfunction’ - Click above on Ovulograph to view the shown graphical introduction to our solution