1. Megakaryocytes predominantly enter the circulation as a large protrusion.
Megakaryocytes predominantly enter the circulation as a large protrusion. (A) Megakaryocyte (M)-intravasating large protrusion (arrowhead) extending into sinusoid lumen (SL). (B) Megakaryocyte (M)-intravasating proplatelet (arrowhead) extending into SL. (C) Free large protrusion (Pr) within SL. (D) Free proplatelet within SL. Scale bars represent 10 μm. (E) Observations of intravasating large protrusions, intravasating proplatelets, free large protrusions, and free proplatelets per 1 mm3 of bone marrow. Bone marrow of the diaphysis region obtained from flushed femurs. Data presented are mean ± SEM. **P < *P < 0.01 (unpaired two-tailed t test, three independent experiments).
Edward Brown et al. LSA 2018;1:e
© 2018 Brown et al.