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Anti-epileptic Drugs Journal of Pain and Symptom Management

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Presentation on theme: "Anti-epileptic Drugs Journal of Pain and Symptom Management"— Presentation transcript:

1 Anti-epileptic Drugs Journal of Pain and Symptom Management
Paul Howard, BMedSci, MRCP, Robert Twycross, DM, FRCP, John Shuster, MD, Mary Mihalyo, BS, PharmD, RPh, Jan Rémi, MD, Andrew Wilcock, DM, FRCP  Journal of Pain and Symptom Management  Volume 42, Issue 5, Pages (November 2011) DOI: /j.jpainsymman Copyright © Terms and Conditions

2 Fig. 1 Mechanisms of action of anti-epileptics and related drugs.1–7,9 Brackets indicate a contributory, but not predominant, action of the anti-epileptic. aAlthough many anti-epileptics have more than one mode of action, valproic acid in particular is thought to have no single predominant action. bT-type calcium channels are responsible for thalamic burst firing (implicated in absence seizures); they are also found in some nociceptors, where they may influence firing thresholds (see text). Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © Terms and Conditions

3 Fig. 2 Management and IV drug treatment of status epilepticus in adults. See text for more detail. Journal of Pain and Symptom Management  , DOI: ( /j.jpainsymman ) Copyright © Terms and Conditions

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