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Vanessa L. Ott, PhD, John C. Cambier, PhD 

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Presentation on theme: "Vanessa L. Ott, PhD, John C. Cambier, PhD "— Presentation transcript:

1 Activating and inhibitory signaling in mast cells: New opportunities for therapeutic intervention? 
Vanessa L. Ott, PhD, John C. Cambier, PhD  Journal of Allergy and Clinical Immunology  Volume 106, Issue 3, Pages (September 2000) DOI: /mai Copyright © 2000 Mosby, Inc. Terms and Conditions

2 Fig. 1 Inhibition of FcϵRI signaling pathways by FcγRIIB. DAG, Diacylglycerol; PKC, protein kinase C; IP3, Ins (3,4,5) P3. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

3 Fig. 2 ITIM-containing inhibitory receptors expressed in mast cells. SHPS-1, src homology 2 domain–containing phosphatase substrate 1; BIT , brain Ig-like molecules with tyrosine-based activation motifs; KLRG1, killer cell lectin-like receptor G1. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions


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