1. Prevention of pancreatic cancer induction in hamsters by metformin
Matthias B. Schneider, Hosei Matsuzaki, James Haorah, Alexis Ulrich, Jens Standop, Xian–Zhong Ding, Thomas E. Adrian, Parviz M. Pour 
Gastroenterology 
Volume 120, Issue 5, Pages (April 2001)
DOI: /gast
Copyright © 2001 American Gastroenterological Association Terms and Conditions

2. Fig. 1
The plasma insulin level in hamsters fed an HF diet before (white bars) and 2 weeks after (gray bars) metformin treatment.
Gastroenterology  , DOI: ( /gast )
Copyright © 2001 American Gastroenterological Association Terms and Conditions

3. Fig. 2
The size of islets in the experimental group compared with age-matched controls. *P < 0.05 vs. control; **P < 0.05 vs. HF.
Gastroenterology  , DOI: ( /gast )
Copyright © 2001 American Gastroenterological Association Terms and Conditions

4. Fig. 3
Intrainsular ductular proliferation in the pancreas of hamsters in the HF group. (A) The ductules were generally cystic. H&E stain, original magnification 75×. (B) Most of the proliferative ductular lesions were surrounded by islet cells (black). ABC method with anti-insulin, original magnification 75×.
Gastroenterology  , DOI: ( /gast )
Copyright © 2001 American Gastroenterological Association Terms and Conditions

5. Fig. 4
Intrainsular ductular structure. (A) Atypical ductular structures of different size and with flat or cuboidal nuclei. H&E stain, original magnification 75×. (B) Hyperplastic and atypical ductular structure in a hamster of the HF group. Note the presence of islet cells within the epithelium of the ductular structures (arrows). H&E stain, original magnification 75×. (C) An intrainsular lesion in another hamster of the HF group depicting many islet cells incorporated into the dysplastic epithelium (arrows). H&E stain, original magnification 120×.
Gastroenterology  , DOI: ( /gast )
Copyright © 2001 American Gastroenterological Association Terms and Conditions

6. Fig. 5
Adenocarcinomas with mixed glandular and insular components. (A) The malignant glands are surrounded by islet cells and show many endocrine cells within the epithelial lining (arrows). Multilabeling technique with anti-insulin (red) and glucagon (brown), original magnification 32×. (B) High power view of a similar lesion in another hamster of the HF group. There is a group of endocrine cells within the epithelium of the malignant gland (arrow). No counter staining was performed for clearer demonstration of immunoreactivity. Multilabeling technique with anti-insulin (brown) and antiglucagon (blue), original magnification 120×.
Gastroenterology  , DOI: ( /gast )
Copyright © 2001 American Gastroenterological Association Terms and Conditions