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Volume 53, Issue 4, Pages (April 1998)

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Presentation on theme: "Volume 53, Issue 4, Pages (April 1998)"— Presentation transcript:

1 Volume 53, Issue 4, Pages 963-969 (April 1998)
Contribution of endothelin receptors in renal microvessels in acute cyclosporine- mediated vasoconstriction in rats  Alessandro Cavarape, Karlhans Endlich, Fabiola Feletto, Niranjan Parekh, Ettore Bartoli, Michael Steinhausen  Kidney International  Volume 53, Issue 4, Pages (April 1998) DOI: /j x Copyright © 1998 International Society of Nephrology Terms and Conditions

2 Figure 1 Percentage changes in renal vascular diameter, glomerular blood flow (GBF) and mean arterial pressure (MAP) at the end of i.v. infusion of BQ-123 () or PD (□). Vessel segments starting from the proximal arcuate artery to the distal efferent arteriole are numbered 1 to 8 (Methods). The break represents the glomerulus. #P < 0.05 versus control, *P < 0.05 PD versus BQ-123. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

3 Figure 2 Time course of changes in mean arterial pressure (MAP) and glomerular blood flow (GBF) due to cyclosporine A (CsA) infusion and during postinfusion periods in the three experimental groups. Pretreatments were: vehicle (•), BQ-123 (□) and PD (▵). #P < 0.05 versus baseline, *P < 0.05 versus vehicle group. In A, # is valid for all groups. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions

4 Figure 3 Changes in vascular diameters due to cyclosporine A (CsA) in animals pretreated with vehicle (▪), with BQ-123 () and with PD (□). The upper panel shows values at the end of CsA infusion for 40 minutes and lower panel values at the end of postinfusion periods at 160 minutes. #P < 0.05 versus baseline, *P < 0.05 vs. vehicle group. Kidney International  , DOI: ( /j x) Copyright © 1998 International Society of Nephrology Terms and Conditions


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