1. The six forms of FSGS. These syndromes include three forms that are most common, including primary FSGS, adaptive FSGS, and APOL1 FSGS. These forms are probably of approximately equal prevalence in the United States adult population.
The six forms of FSGS. These syndromes include three forms that are most common, including primary FSGS, adaptive FSGS, and APOL1 FSGS. These forms are probably of approximately equal prevalence in the United States adult population. Three forms are less common, including genetic FSGS (by which is meant high-penetrance genetic causes), medication-associated FSGS, and viral FSGS. The approximate relative distribution of these variants in the United States population at present is shown by the size each cloud, although firm data on prevalence are lacking. The absolute frequency of these FSGS forms is influenced by race/ethnicity (particularly in the frequency of APOL1 risk variants), age (children are less likely to have adaptive FSGS), and the frequency of exposures to toxins (e.g., heroin) and medications and having viruses (e.g., HIV).
Avi Z. Rosenberg, and Jeffrey B. Kopp CJASN 2017;12:
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