1. Model of DHA-mediated peroxisome division.
Model of DHA-mediated peroxisome division. DHA promotes the oligomerization of Pex11pβ, which leads to the formation of Pex11pβ-rich regions and initiates peroxisome elongation (steps 1 and 2), in which peroxisomes elongate in one direction (step 3). The elongation of peroxisomes activates DLP1 to cleave peroxisomal membranes, thereby giving rise to peroxisomal fission (step 4). After division, daughter peroxisomes translocate via microtubules (MT) (step 5). See Discussion for details.
Akinori Itoyama et al. J Cell Sci 2012;125:
© 2012.