1. Two methacholine dosing schemes.
Two methacholine dosing schemes. Methacholine may be administered in 9 doubling doses from mg/mL up to 16 mg/mL or using a quadrupling scheme with 5 doses ranging from mg/mL up to 16 mg/mL. A similar scheme can be used for histamine challenge. Not shown is an optional diluent step; normal saline or similar is administered before the first dose of methacholine and used to establish the target FEV1 for calculating a 20% decrease. Data are from Reference 30.
Gregg L Ruppel Respir Care 2015;60:
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