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Mometasone furoate administered once daily is as effective as twice-daily administration for treatment of mild-to-moderate persistent asthma  James P.

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Presentation on theme: "Mometasone furoate administered once daily is as effective as twice-daily administration for treatment of mild-to-moderate persistent asthma  James P."— Presentation transcript:

1 Mometasone furoate administered once daily is as effective as twice-daily administration for treatment of mild-to-moderate persistent asthma  James P. Kemp, MDa, Robert B. Berkowitz, MDb, S.David Miller, MDc, John J. Murray, MD, PhDd, Keith Nolop, MDe, Judy E. Harrison, MDe  Journal of Allergy and Clinical Immunology  Volume 106, Issue 3, Pages (September 2000) DOI: /mai Copyright © 2000 Mosby, Inc. Terms and Conditions

2 Fig. 1 Effect of MF-DPI treatment on mean change in FEV1. Mean ± SEM changes in FEV1 from baseline at each treatment visit and at endpoint are shown. Squares, MF-DPI 200 μg once daily morning treatment; diamonds, MF-DPI 400 μg once daily morning treatment; triangles, MF-DPI 200 μg twice daily treatment; circles, placebo. *P ≤ .02 versus placebo. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

3 Fig. 2 Effect of MF-DPI treatment on mean change in morning PEF. Mean ± SEM changes in morning PEF from baseline at each treatment visit and at endpoint are shown. Squares, MF-DPI 200 μg once daily morning treatment; diamonds, MF-DPI 400 μg once daily morning treatment; triangles, MF-DPI 200 μg twice daily treatment; circles, placebo. *P < .01 versus MF-DPI 200 μg once daily morning treatment and placebo; +P = .04 versus placebo. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions

4 Fig. 3 Effect of MF-DPI treatment on Kaplan-Meier estimates of time to worsening. All MF-DPI treatment groups had a greater probability of remaining in the study (P < .01) compared with placebo. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2000 Mosby, Inc. Terms and Conditions


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