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Phosphoribosomes for Fingerprinting Neurons

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Presentation on theme: "Phosphoribosomes for Fingerprinting Neurons"— Presentation transcript:

1 Phosphoribosomes for Fingerprinting Neurons
Marcelo O. Dietrich, Tamas L. Horvath  Cell  Volume 151, Issue 5, Pages (November 2012) DOI: /j.cell Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Representation of the Phosphorylated Ribosome Capture Technique Silent neurons have decreased ribosome activity, which is represented by low levels of S6 phosphorylation. When neurons are activated via specific stimuli, S6 becomes phosphorylated, and immunoprecipitation of the ribosome complex with pS6 antibodies yields mRNA synthesized during activation. By combining behavioral tasks or other tools to manipulate cell activity, it is possible to pull down ribosomes from target areas in the brain to identify the molecular profile of activated cells under the given circumstance. After validation of genes identified during molecular profiling, animal models can be generated to further manipulate and study the circuitry. Subsequently, techniques to activate or deactivate neurons can be used to test the role of a specific subset of cells in behavior and other regulatory systems. It is also possible to combine these techniques with tracing technologies to investigate projection fields. Cell  , DOI: ( /j.cell ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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