1. The mechanism of action for TRIO, CHKA and BMX lies between the AT1R and EGFR. (A) Our hypothesis is that TRIO, CHKA and BMX lie between the activated AT1R and EGFR and thus modulate the AT1R–EGFR transactivation response.
The mechanism of action for TRIO, CHKA and BMX lies between the AT1R and EGFR. (A) Our hypothesis is that TRIO, CHKA and BMX lie between the activated AT1R and EGFR and thus modulate the AT1R–EGFR transactivation response. A proposed model for this theory is illustrated. (B) HMEC-LST-AT1R cells were transfected with siGFP, siTRIO, siCHKA or siBMX SMARTpool siRNAs for 72 hours and stimulated with either AngII (100 nM) or EGF ligand (0.5 ng/ml) for 10 minutes. Knockdown of TRIO (B), BMX (C) or CHKA (D) did not alter the response of the cells to 0.5 ng/ml EGF ligand. Data are representative of three independent experiments.
Amee J. George et al. J Cell Sci 2013;126:
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