1. Genetic synteny is highly conserved between TLPQC (transmissible loci for protein quality control).
Genetic synteny is highly conserved between TLPQC (transmissible loci for protein quality control). The synteny of the TLPQC is highly conserved, suggesting an origin of horizontal gene transfer between several genera (Salmonella, Methylobacillus, Cronobacter, Escherichia, and Klebsiella). Despite reductions in the loci, the synteny of the loci is conserved in the various clades. Conserved ORFs with predicted functions are colored in the figure. The functions are indicated by the following letters (and colors): A, small heat shock proteins (dark blue); B, Clp protease (green); C, cardiolipin synthase (teal); D, FtsH protease (pink); E, YfdX family protein (magenta); F, thioredoxin (black); G, KefB glutathione-regulated potassium efflux pump (purple); H, Zn-dependent protease (red); and I, periplasmic serine protease (dark green). Letters within parentheses indicate that the gene is truncated. The E. coli AW 1.7 nucleotide accession number is NZ_LDYJ
Scott V. Nguyen et al. mSystems 2017; doi: /mSystems