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Effect of dose level on the anti-keyhole limpet haemocyanin (KLH) IgG response in the multiple-ascending dose (MAD) study. Effect of dose level on the.

Published byΞάνθη Γερμανού Modified over 5 years ago

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Presentation on theme: "Effect of dose level on the anti-keyhole limpet haemocyanin (KLH) IgG response in the multiple-ascending dose (MAD) study. Effect of dose level on the."— Presentation transcript:

1 Effect of dose level on the anti-keyhole limpet haemocyanin (KLH) IgG response in the multiple-ascending dose (MAD) study. Effect of dose level on the anti-keyhole limpet haemocyanin (KLH) IgG response in the multiple-ascending dose (MAD) study. (A) anti-KLH IgG serum values by individual cohort in the MAD study (uncensored). (B) Anti-KLH IgG serum values by individual cohort in the MAD study with the nine (of 51) pre-existing (ie, pre-immunisation) anti-KLH IgG-positive subjects removed. For both graphs, data are shown by study day (x-axis) and the anti-KLH IgG mean±SEM (y-axis), the dose level is indicated in the legend and the number of samples per symbol are shown in parentheses. (C) Mean area under the curve (AUC) (±SEM) of the serum anti-KLH IgG from the first KLH to 112 days after the first KLH (y-axis) is shown versus the mean AUC (±SEM) AMG 557 serum concentration from study day 1 to 112 days after the first KLH for the single-ascending dose (SAD) and the MAD studies. Pre-immunisation anti-KLH IgG-positive subjects from both studies were excluded from the analysis. B A Sullivan et al. Lupus Sci Med 2016;3:e000146 ©2016 by Lupus Foundation of America

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