1. End Points: ONTARGET vs. HOPE *
Ram
Tel
Tel vs Ram
N (%)
RR (95% CI)
P (non-inf) N
8576
8542
ONTARGET Primary Outcome
CV Death, MI, Stroke, CHF Hosp
1412 (16.46%)
1423 (16.66%)
1.01 ( )
0.0038
(Adjusted for SBP)
1.02 ( )
0.0055
HOPE Primary Outcome
CV Death, MI, Stroke
1210 (14.11%)
1190 (13.93%)
0.99 ( )
0.0009
0.0012
*Whether telmisartan is compared to ramipril for the primary outcome defined in ONTARGET or the primary outcome used in HOPE, the relative protection did not differ.
Adapted from Yusuf S. ACC 2008.

2. ONTARGET Non-Inferiority Margins
Primary Composite
(P=0.004)
CV Death / MI / Stroke
(P=<0.001)
(HOPE Composite)
Telmisartan better
Ramipril better
0.8
0.9
1.0
1.1
1.2
RR (95% CI)
Adapted from Yusuf S. ACC 2008.