1. Comparable function of intrahepatic and intraomental islets transplanted into biologic scaffolds.
Comparable function of intrahepatic and intraomental islets transplanted into biologic scaffolds. Nonfasting blood glucose levels in diabetic rats receiving a clinically relevant syngeneic islet mass of 1,300 IEQ (∼8,200 IEQ/kg body wt) within an intraomental biologic scaffold (A) (●, n = 7) or into the liver (via the portal vein) (B) (○, n = 5) with islets from the same batch isolation. The groups had an identical time course for reversal of diabetes, and removal of the intraomental biologic scaffold on day 80 posttransplant resulted in return to hyperglycemia (arrowhead in A). Glycemic profile during OGTT performed in all transplanted animals 5 (C) or 11 weeks (D) after transplantation. Inset shows AUC (mg × min × dL−1) during the glucose challenge for each group. wks, weeks.
Dora M. Berman et al. Diabetes 2016;65:
©2016 by American Diabetes Association