1. Starvation-induced inhibition of leptin transport across the BBB is caused by a circulating factor.
Starvation-induced inhibition of leptin transport across the BBB is caused by a circulating factor. A: Replication of classic work (20) showing that the leptin transporter is inhibited with starvation. B: With brain perfusion, a method that negates the effect of circulating substances, the transporter returns to normal. C: Triglyceride levels in serum in control mice, mice fasted for 16 h, and mice fasted for 48 h. IV, intravenous. *P < 0.05; **P < 0.01.
William A. Banks et al. Diabetes 2004;53:
©2004 by American Diabetes Association