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Effects of the hindlimb-unloading model of spaceflight conditions on resistance of mice to infection with Klebsiella pneumoniae  Tesfaye Belay, PhD, Hernan.

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Presentation on theme: "Effects of the hindlimb-unloading model of spaceflight conditions on resistance of mice to infection with Klebsiella pneumoniae  Tesfaye Belay, PhD, Hernan."— Presentation transcript:

1 Effects of the hindlimb-unloading model of spaceflight conditions on resistance of mice to infection with Klebsiella pneumoniae  Tesfaye Belay, PhD, Hernan Aviles, MD, PhD, Monique Vance, BS, Kimberly Fountain, BS, Gerald Sonnenfeld, PhD  Journal of Allergy and Clinical Immunology  Volume 110, Issue 2, Pages (August 2002) DOI: /mai Copyright © 2002 Mosby, Inc. Terms and Conditions

2 Fig. 1 Effect of hindlimb unloading on survival of mice after intraperitoneal administration of K pneumoniae 2 days after treatment. Data were expressed as percentage survival at each time point, as determined by using the Kaplan-Meier method. Differences in survival among the 3 experimental groups of mice were compared by using the Mantel-Cox log-rank test. Squares, Hindlimb-unloaded and infected mice; circles, restrained and infected mice; triangles, normally caged control and infected mice. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

3 Fig. 2 Average period to death of mice after intraperitoneal administration of K pneumoniae 2 days after hindlimb unloading. Each time point represents the mean ± SE, and values are expressed in days. *Statistically significant difference. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

4 Fig. 3 Organ distribution of K pneumoniae in mice 2 days after hindlimb unloading. CFU counts in bloods (A) , liver (B) , spleen (C) , lung (D) , kidney (E) , and brains (F) . Each time point represents the mean ± SE of CFUs per milliliter of 2 or more mice. Squares, Hindlimb-unloaded and infected mice; circles, restrained and infected mice; triangles, normally caged control and infected mice. Journal of Allergy and Clinical Immunology  , DOI: ( /mai ) Copyright © 2002 Mosby, Inc. Terms and Conditions

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