Presentation is loading. Please wait.

Presentation is loading. Please wait.

Metformin and rapamycin decreased tumor weights in obese prediabetic mice. Metformin and rapamycin decreased tumor weights in obese prediabetic mice. A:

Published byMarcel Bařtipán Modified over 5 years ago

Similar presentations

Presentation on theme: "Metformin and rapamycin decreased tumor weights in obese prediabetic mice. Metformin and rapamycin decreased tumor weights in obese prediabetic mice. A:"— Presentation transcript:

1 Metformin and rapamycin decreased tumor weights in obese prediabetic mice.
Metformin and rapamycin decreased tumor weights in obese prediabetic mice. A: Scatterplot depicting tumor weights measured at study termination in mice receiving either metformin (250 mg/kg, n = 14), rapamycin (2.5 mg/kg, n = 14), or vehicle (0.1% DMSO in saline, n = 11). B and C: Representative images of pancreatic tumors analyzed by immunohistochemical staining of pAkt, pmTOR, and pACC. C: Quantification of pAkt, pmTOR, and pACC positively stained cells in tumor tissues. Original magnification ×40. Scale bar represents 100 nm. Data are expressed as mean ± SEM number of positive cells per field in tumors (n = 8 per group). *P < 0.05 by one-way ANOVA. Vincenza Cifarelli et al. Diabetes 2015;64: ©2015 by American Diabetes Association

Download ppt "Metformin and rapamycin decreased tumor weights in obese prediabetic mice. Metformin and rapamycin decreased tumor weights in obese prediabetic mice. A:"

Similar presentations

Altered cell migration factors and increased intestinal tumorigenesis in APC1638N/+ mice. Altered cell migration factors and increased intestinal tumorigenesis.

Altered cell migration factors and increased intestinal tumorigenesis in APC1638N/+ mice. Altered cell migration factors and increased intestinal tumorigenesis.
25(OH)D and 1,25(OH)2D perfusion treatment effect on cancer-related markers: IF stains illustrating expression levels for Ki-67 (A), cyclin D1 (B), ErbB-2.

25(OH)D and 1,25(OH)2D perfusion treatment effect on cancer-related markers: IF stains illustrating expression levels for Ki-67 (A), cyclin D1 (B), ErbB-2.
Combined PLX3397 and PTX treatment inhibits metastasis in a CD8-dependent manner. Combined PLX3397 and PTX treatment inhibits metastasis in a CD8-dependent.

Combined PLX3397 and PTX treatment inhibits metastasis in a CD8-dependent manner. Combined PLX3397 and PTX treatment inhibits metastasis in a CD8-dependent.
Effects of AG-221 treatment on survival and cell differentiation in an IDH2R140Q primary human AML xenograft model. Effects of AG-221 treatment on survival.

Effects of AG-221 treatment on survival and cell differentiation in an IDH2R140Q primary human AML xenograft model. Effects of AG-221 treatment on survival.
Effects of SC144 on in vivo ovarian tumor.

Effects of SC144 on in vivo ovarian tumor.
Fig. 5. Pharmacological JAK2 inhibition in vivo abrogates tumor-initiating potential after chemotherapy. Pharmacological JAK2 inhibition in vivo abrogates.

Fig. 5. Pharmacological JAK2 inhibition in vivo abrogates tumor-initiating potential after chemotherapy. Pharmacological JAK2 inhibition in vivo abrogates.
Fig. 4 DMF enhances VSVΔ51 therapeutic efficacy in syngeneic and xenograft tumor models. DMF enhances VSVΔ51 therapeutic efficacy in syngeneic and xenograft.

Fig. 4 DMF enhances VSVΔ51 therapeutic efficacy in syngeneic and xenograft tumor models. DMF enhances VSVΔ51 therapeutic efficacy in syngeneic and xenograft.
Fig. 5 Local gel scaffold for T cell memory response.

Fig. 5 Local gel scaffold for T cell memory response.
Cardiac Fibrosis at 18 Weeks Post TAC (A) Representative images (original magnification ×20) of Picrosirius red-stained cardiac tissue sections from HF +

Cardiac Fibrosis at 18 Weeks Post TAC (A) Representative images (original magnification ×20) of Picrosirius red-stained cardiac tissue sections from HF +
TANs mediate obesity-induced tumor progression and aggravated desmoplasia. TANs mediate obesity-induced tumor progression and aggravated desmoplasia. A,

TANs mediate obesity-induced tumor progression and aggravated desmoplasia. TANs mediate obesity-induced tumor progression and aggravated desmoplasia. A,
Fig. 6. pKL cells revert hyperglycemia in NOD mice in vivo.

Fig. 6. pKL cells revert hyperglycemia in NOD mice in vivo.
Enhancement of receptor endocytosis, as well as cellular apoptosis, may explain the cooperative anti‐tumor actions of 3×mAbs and osimertinib Enhancement.

Enhancement of receptor endocytosis, as well as cellular apoptosis, may explain the cooperative anti‐tumor actions of 3×mAbs and osimertinib Enhancement.
Fig. 2. IL-2/rapamycin–expanded T cells express homing receptors to traffic to lymphoma sites and are resistant to SN-38 toxicity. IL-2/rapamycin–expanded.

Fig. 2. IL-2/rapamycin–expanded T cells express homing receptors to traffic to lymphoma sites and are resistant to SN-38 toxicity. IL-2/rapamycin–expanded.
Renal Fibrosis and Plasma Creatinine Levels at 18 Weeks Post TAC (A) Plasma creatinine levels. (B) Representative images (original magnification ×20) of.

Renal Fibrosis and Plasma Creatinine Levels at 18 Weeks Post TAC (A) Plasma creatinine levels. (B) Representative images (original magnification ×20) of.
Effect of antiangiogenic TKIs and rMVA–CEA–TRICOM vaccine on tumor compactness, tight junctions, and intratumoral pressure in the MC38-CEA model. Effect.

Effect of antiangiogenic TKIs and rMVA–CEA–TRICOM vaccine on tumor compactness, tight junctions, and intratumoral pressure in the MC38-CEA model. Effect.
NICD1 immunohistochemical staining in normal and tumor tissue.

NICD1 immunohistochemical staining in normal and tumor tissue.
NRP1-expressing myeloid cells influence adipocyte hypertrophy, development of fatty liver, and CLSs. NRP1-expressing myeloid cells influence adipocyte.

NRP1-expressing myeloid cells influence adipocyte hypertrophy, development of fatty liver, and CLSs. NRP1-expressing myeloid cells influence adipocyte.
ILK knockdown decreases mTOR signaling in PKD kidneys.

ILK knockdown decreases mTOR signaling in PKD kidneys.
The oligoclonal antibody overcomes the C797S mutation‐mediated resistance to osimertinib The oligoclonal antibody overcomes the C797S mutation‐mediated.

The oligoclonal antibody overcomes the C797S mutation‐mediated resistance to osimertinib The oligoclonal antibody overcomes the C797S mutation‐mediated.
UCN‐01 inhibits human IPF lung fibroblast pathological phenotypes and attenuates lung fibrosis induced by bleomycin injury UCN‐01 inhibits human IPF lung.

UCN‐01 inhibits human IPF lung fibroblast pathological phenotypes and attenuates lung fibrosis induced by bleomycin injury UCN‐01 inhibits human IPF lung.

Similar presentations

Ads by Google