1. Somatostatin released by δ-cells exerts a tonic inhibition on glucagon and insulin secretion but is not required for the glucagonostatic effect of glucose (G).
Somatostatin released by δ-cells exerts a tonic inhibition on glucagon and insulin secretion but is not required for the glucagonostatic effect of glucose (G). Islets from Sst+/+ or Sst−/− mice were perifused in the presence of alanine, glutamine, and arginine (2 mmol/L each, mix AA). The G concentration was changed between 1 and 7 mmol/L as indicated. B: Glucagon secretion from the experiments illustrated in (A) is expressed as percentage of secretion during the last 12 min in G1. Traces are means ± SE for three (Sst+/+) or five (Sst−/−) experiments with islets from different preparations.
Rui Cheng-Xue et al. Diabetes 2013;62:
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