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Tight junctions Current Biology

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Presentation on theme: "Tight junctions Current Biology"— Presentation transcript:

1 Tight junctions Current Biology
James M. Anderson, Christina M. Van Itallie  Current Biology  Volume 18, Issue 20, Pages R941-R943 (October 2008) DOI: /j.cub Copyright © 2008 Elsevier Ltd Terms and Conditions

2 Figure 1 The tight junction barrier is formed by continuous rows of claudin proteins which ring the apical end of the cell. Different claudin gene products, depicted in different colors, assemble in the barrier and create paracellular pores through their extracellular contacts (shown on the left). Claudin, and other types of strand proteins, are attached to multi-PDZ proteins and the actin cytoskeleton (right). Many other functional classes of proteins are found at TJs. Current Biology  , R941-R943DOI: ( /j.cub ) Copyright © 2008 Elsevier Ltd Terms and Conditions


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