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PD1 targeting alters the recruitment of immune cells to MC38 CRC tumors. PD1 targeting alters the recruitment of immune cells to MC38 CRC tumors. MC38.

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Presentation on theme: "PD1 targeting alters the recruitment of immune cells to MC38 CRC tumors. PD1 targeting alters the recruitment of immune cells to MC38 CRC tumors. MC38."— Presentation transcript:

1 PD1 targeting alters the recruitment of immune cells to MC38 CRC tumors.
PD1 targeting alters the recruitment of immune cells to MC38 CRC tumors. MC38 tumors in C57/BL6 mice treated with GKT771, anti-PD1 antibody, a combination thereof, and the corresponding controls. (A) The cells were isolated from tumors and stained with antibodies for CD45, CD11b, F4/80, and CD68. (A) Ratios of CD45+/CD11b+/CD68+/F4/80+ and CD45+/CD11b+/CD68+/F4/80− TAMs. (B) Ratios of CD45+/CD11b+/F4/80+ and CD45+/CD11b+/F4/80− macrophages. Jimmy Stalin et al. LSA 2019;2:e © 2019 Stalin et al.

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S2 Fig. Phenotype of donor cells in the spleen and bone marrow of male mice. Splenocytes and bone marrow were isolated from male donor mice and stained.

S2 Fig. Phenotype of donor cells in the spleen and bone marrow of male mice. Splenocytes and bone marrow were isolated from male donor mice and stained.
AF647-RIS is internalized by TAMs in vivo.

AF647-RIS is internalized by TAMs in vivo.
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Synergistic antitumor effect of anti-CD40/CpG and 14
Selinexor combines with immune checkpoint blockade to slow B16F10 melanoma tumor growth. Selinexor combines with immune checkpoint blockade to slow B16F10.

Selinexor combines with immune checkpoint blockade to slow B16F10 melanoma tumor growth. Selinexor combines with immune checkpoint blockade to slow B16F10.
Anti–4-1BB/PD-1 combination enriched CD8+ T cells in TILs

Anti–4-1BB/PD-1 combination enriched CD8+ T cells in TILs
Early studies evaluating role of immune infiltrate in colorectal cancer

Early studies evaluating role of immune infiltrate in colorectal cancer
Nat. Rev. Clin. Oncol. doi: /nrclinonc

Nat. Rev. Clin. Oncol. doi: /nrclinonc
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IHC staining of FFPE esophageal tissues in tissue microarrays (×20).
Frequencies of immune cell types show much stronger variations between tumor types in the tumor infiltrate compared with the spleen and tumor-draining.

Frequencies of immune cell types show much stronger variations between tumor types in the tumor infiltrate compared with the spleen and tumor-draining.
Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. AT-3ovadim.

Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. AT-3ovadim.
H31m1-PDL1 cells form progressively growing tumors in WT mice.

H31m1-PDL1 cells form progressively growing tumors in WT mice.
Fig. 5 A competent Fc is required for the antitumor immune response.

Fig. 5 A competent Fc is required for the antitumor immune response.
Functions of myeloid cells.

Functions of myeloid cells.
Gr-1+ MDSC in tumor-bearing mice produce IL-6.

Gr-1+ MDSC in tumor-bearing mice produce IL-6.
Fig. 5 Combination intravenous reovirus and checkpoint inhibition in an orthotopic syngeneic brain tumor model. Combination intravenous reovirus and checkpoint.

Fig. 5 Combination intravenous reovirus and checkpoint inhibition in an orthotopic syngeneic brain tumor model. Combination intravenous reovirus and checkpoint.
The absence of ADCC by nivolumab in vitro.

The absence of ADCC by nivolumab in vitro.
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Immune cell populations, activation, and NKG2D and H60a expression in the spleen of untreated and antibiotic-treated Klrk1+/+ and Klrk1−/− NOD mice. Immune.
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1 Oncomine database: DKK2 upregulation in colorectal cancers(CRC)

1 Oncomine database: DKK2 upregulation in colorectal cancers(CRC)
Fig. 4 Surgery initiates a systemic inflammatory response that triggers the outgrowth of distant immunogenic tumors and can be inhibited by perioperative.

Fig. 4 Surgery initiates a systemic inflammatory response that triggers the outgrowth of distant immunogenic tumors and can be inhibited by perioperative.

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