1. NOD.hCD205 mice are susceptible to T1D.
NOD.hCD205 mice are susceptible to T1D. (A) Diabetes incidence curves for female NOD and NOD.hCD205 littermates are shown. p = 0.72 (Mantel–Cox). (B) To verify the presence of diabetogenic T cells in NOD.hCD205 mice, islet-infiltrating T cells from three female NOD.hCD205 mice were added to NOD DCs that were incubated with the indicated peptides, and T cell reactivity was measured by IFN-γ ELISPOT. Graph displays stimulation index for each peptide (mean + SEM of triplicates); dotted line indicates a stimulation index of 2. TUM (KYQAVTTTL) is an irrelevant H2-Kd–binding peptide; TRL9 (TSPRNSTVL) is an irrelevant H2-Db–binding peptide.
Jennifer Schloss et al. ImmunoHorizons 2019;3:
Copyright © 2019 The Authors