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FIGURE 2 Regression of age- and sex-adjusted mean BMI (A) and WC (B) across obesity (BMI) GRSs. Black dots: age- and ... FIGURE 2 Regression of age- and.

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Presentation on theme: "FIGURE 2 Regression of age- and sex-adjusted mean BMI (A) and WC (B) across obesity (BMI) GRSs. Black dots: age- and ... FIGURE 2 Regression of age- and."— Presentation transcript:

1 FIGURE 2 Regression of age- and sex-adjusted mean BMI (A) and WC (B) across obesity (BMI) GRSs. Black dots: age- and ... FIGURE 2 Regression of age- and sex-adjusted mean BMI (A) and WC (B) across obesity (BMI) GRSs. Black dots: age- and sex-adjusted mean BMI ± SEM (A) and age- and sex-adjusted mean WC ± SEM (B) in each obesity (BMI) GRS category (n = 768). Black line: the linear regression between GRS and BMI adjusted for age and sex (β = 0.19 ± 0.04, P < 0.0001, R<sup>2 </sup>= 2.50%), n = 768 (A) and the linear regression between GRS and WC adjusted for age and sex (β = 0.46 ± 0.10, P < 0.0001, R<sup>2 </sup>= 2.81%), n = 754 (B). The GRS was calculated by adding up the number of risk alleles (i.e., 0, 1, or 2) at each of the 97 obesity-related single nucleotide polymorphisms identified in the most recent meta-analysis of BMI. GRS, genetic risk score; WC, waist circumference. Unless provided in the caption above, the following copyright applies to the content of this slide: © 2018 American Society for Nutrition.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Am J Clin Nutr, Volume 108, Issue 3, 05 July 2018, Pages 445–452, The content of this slide may be subject to copyright: please see the slide notes for details.

2 FIGURE 1 Flowchart diagram of participant selection
FIGURE 1 Flowchart diagram of participant selection. The GRS was calculated by adding up the number of risk alleles ... FIGURE 1 Flowchart diagram of participant selection. The GRS was calculated by adding up the number of risk alleles (i.e., 0, 1, or 2) at each of the 97 obesity-related single nucleotide polymorphisms identified in the most recent meta-analysis of BMI. GRS, genetic risk score of obesity. Unless provided in the caption above, the following copyright applies to the content of this slide: © 2018 American Society for Nutrition.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Am J Clin Nutr, Volume 108, Issue 3, 05 July 2018, Pages 445–452, The content of this slide may be subject to copyright: please see the slide notes for details.

3 FIGURE 3 Mediation models of the association between GRS of obesity and BMI or WC. (A) Mediation effect of ... FIGURE 3 Mediation models of the association between GRS of obesity and BMI or WC. (A) Mediation effect of disinhibition on the association between GRS and BMI, (B) mediation effect of disinhibition on the association between GRS and WC, (C) mediation effect of susceptibility to hunger on the association between GRS and BMI, and (D) mediation effect of susceptibility to hunger on the association between GRS and WC. Mediations are from linear regression models. All regression analyses were adjusted for age and sex. c’ represents the association between GRS and BMI (A, C) or WC (B, D) when the mediating variable (i.e., disinhibition or susceptibility to hunger) is in the model. The product of a and b paths (a × b) represents the mediation effect (or the indirect effect) of EB traits on the association between GRS and BMI or WC and the significant mediation effect is assessed by the Sobel test. n = 598–601. The GRS was calculated by adding up the number of risk alleles (i.e., 0, 1, or 2) at each of the 97 obesity-related single nucleotide polymorphisms identified in the most recent meta-analysis of BMI. GRS, genetic risk score; WC, waist circumference. Unless provided in the caption above, the following copyright applies to the content of this slide: © 2018 American Society for Nutrition.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( Am J Clin Nutr, Volume 108, Issue 3, 05 July 2018, Pages 445–452, The content of this slide may be subject to copyright: please see the slide notes for details.

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