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The relative importance of graft surveillance and warfarin therapy in infrainguinal prosthetic bypass failure  Robert Scott Brumberg, DO, Martin R. Back,

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Presentation on theme: "The relative importance of graft surveillance and warfarin therapy in infrainguinal prosthetic bypass failure  Robert Scott Brumberg, DO, Martin R. Back,"— Presentation transcript:

1 The relative importance of graft surveillance and warfarin therapy in infrainguinal prosthetic bypass failure  Robert Scott Brumberg, DO, Martin R. Back, MD, Paul A. Armstrong, DO, David Cuthbertson, MS, Murray L. Shames, MD, Brad L. Johnson, MD, Dennis F. Bandyk, MD  Journal of Vascular Surgery  Volume 46, Issue 6, Pages (December 2007) DOI: /j.jvs Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 Kaplan-Meier estimates of primary, assisted, and secondary patency for 130 infrainguinal polytetrafluoroethylene bypasses according to duplex surveillance. The number of at-risk bypasses is shown at 6 months and annual follow-up intervals; standard error (SE) remained less than 10% until 4 years. Significant patency augmentation (log rank; P = .025) was accomplished through secondary interventions on stenotic and occluded bypasses. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Thrombotic outcome of low-flow (midgraft peak velocity ≤45 cm/s) infrainguinal bypasses (n = 61). A significant patency benefit was seen for therapeutic warfarin over subtherapeutic or no anticoagulation (sub/no) for both above-knee popliteal (P = .03) and below-knee target grafts (P = .0004). Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Thrombotic outcome of high-flow (midgraft peak velocity >45 cm/s) bypasses (n = 69). No additional benefit of therapeutic warfarin was found for infrainguinal bypasses (P = .15), including above-knee (P = .27) and below-knee (P = .38) target subgroups. Sub/no, Subtherapeutic or no anticoagulation. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

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