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In vivo effects of glucocorticoids on IgE production

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1 In vivo effects of glucocorticoids on IgE production
Zieg, MD, Lack, MD, Harbeck, PhD, Gelfand, MD, Leung, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 94, Issue 2, Pages (August 1994) DOI: /ai.1994.v94.a54936

2 FIG. 1 Effect of prednisone on serum IgE (A) and IgG (B) levels. Ten patients with asthma were given a course of 20 mg of prednisone two times a day for 7 days. Serum immunoglobulins were drawn before and after prednisone treatment. All patients showed a significant increase in serum IgE levels (p = 0.005) but no significant change in serum IgG levels (p = 0.4). Journal of Allergy and Clinical Immunology  , DOI: ( /ai.1994.v94.a54936)

3 FIG. 2 Effect of prednisone on serum allergen-specific IgE levels. Allergen-specific IgE was measured in 10 patients with asthma. The polyclonal IgE responses of four representative patients to the different allergens tested are shown (p = ). Journal of Allergy and Clinical Immunology  , DOI: ( /ai.1994.v94.a54936)

4 FIG. 3 Effect of prednisone on IFN-γ (A) and IL-4 (B) synthesis. PBMCs (1 × 106 cells/ml) from 10 patients with asthma were cultured before and after a course of prednisone in the presence of concanavalin A (10 μg/ml) for 48 hours, after which supernatants were analyzed for IFN-γ and IL-4 levels by ELISA. IFN-γ, but not IL-4 (p = 0.6), synthesis was decreased in all patients (p = 0.005). Journal of Allergy and Clinical Immunology  , DOI: ( /ai.1994.v94.a54936)

5 FIG. 4 Effect of prednisone on the frequency of IFN-γ–(A) and IL-4–(B) producing PBMCs. Intracellular staining for cytokine production was performed on serum samples from six patients. After prednisone treatment, the frequency of PBMCs producing IFN-γ, but not IL-4 (p = 1.0), was decreased (p = 0.03). Journal of Allergy and Clinical Immunology  , DOI: ( /ai.1994.v94.a54936)

6 FIG. 5 Effect of prednisone on frequency of IFN-γ on different lymphocyte subpopulations. Intracellular staining for IFN-γ production was performed on serum samples from six patients. After prednisone treatment, the frequency of CD3(+) (A) and CD3(–) (B) IFN-γ–producing cells was decreased (p = 0.03). Journal of Allergy and Clinical Immunology  , DOI: ( /ai.1994.v94.a54936)

7 FIG. 6 Regression analysis comparing the change in FEV1 with the rise in serum IgE. Eight patients with asthma performed pulmonary function studies before and after a course of prednisone. Regression analysis was performed to determine whether the rise in serum IgE had an effect on the results of pulmonary function studies. There was a direct correlation between these two variables (r = 0.76, p = 0.03). Journal of Allergy and Clinical Immunology  , DOI: ( /ai.1994.v94.a54936)

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