1. Effect of particle size on the prolonged action of subcutaneous danazol in male and female rats 
George M Butterstein, Ph.D., V.Daniel Castracane, Ph.D. 
Fertility and Sterility 
Volume 74, Issue 2, Pages (August 2000)
DOI: /S (00)

2. Figure 1
Serum LH levels in castrated male rats after a single subcutaneous injection of vehicle, danazol with a particle size of 2.05 μm (particle #1), or danazol with a particle size of 5.2 μm (particle #2). The larger-particle danazol suppressed LH levels for the entire 35 days of the study (P<.001), whereas LH levels increased after 25 days in animals that received the smaller-particle danazol.
Butterstein. Effect of danazol particle size. Fertil Steril 2000.
Fertility and Sterility  , DOI: ( /S (00) )

3. Figure 2
Estrous cycle length in female rats that received danazol with a particle size of 2.05 μm (particle #1), or danazol with a particle size of 5.2 μm (particle #2). The normal estrous cycle of 4.8 ± 0.40 days was prolonged to 38.7 ± 0.95 days (P<.001) after injection of larger-particle danazol, whereas smaller-particle danazol inhibited estrus for 25.5 ± 3.1 days. The results of Tukey-Kramer post hoc analysis comparing all mean differences (particle #1 vs. particle #2, particle #1 vs. vehicle, and particle #2 vs. vehicle) were significant (P<.05).
Butterstein. Effect of danazol particle size. Fertil Steril 2000.
Fertility and Sterility  , DOI: ( /S (00) )