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Wasp venom immunotherapy expands a subpopulation of CD4+CD25+ forkhead box protein 3–positive regulatory T cells expressing the T-cell receptor Vβ2 and.

Published byVerawati Sanjaya Modified over 5 years ago

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Presentation on theme: "Wasp venom immunotherapy expands a subpopulation of CD4+CD25+ forkhead box protein 3–positive regulatory T cells expressing the T-cell receptor Vβ2 and."— Presentation transcript:

1 Wasp venom immunotherapy expands a subpopulation of CD4+CD25+ forkhead box protein 3–positive regulatory T cells expressing the T-cell receptor Vβ2 and Vβ5.1 chains  Andreas Kerstan, MD, Niklas Beyersdorf, MD, Johanna Stoevesandt, MD, Axel Trautmann, MD  Journal of Allergy and Clinical Immunology  Volume 130, Issue 4, Pages e3 (October 2012) DOI: /j.jaci Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 TCR Vβ use in memory Treg and memory T cells. A, Gating approach for CD4+CD25+Foxp3+ T cells. Percentages of CD25+ and Foxp3+ T cells are indicated, respectively. cts, Counts. B, Significant increase in Vβ2- and Vβ5.1-expressing memory Treg cells after 1 month (T1) of VIT. N = 20 (T0 and T1) and n = 9 (T6). *P < .05 (repeated-measures ANOVA, followed by the Tukey-Kramer test). Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig E1 TCR Vβ chain expression of CD3+CD4+ T cells. TCR Vβ repertoire was analyzed by costaining with 24 different anti-TCR Vβ antibodies before and 1 month after starting VIT. Each circle represents 1 patient. Dashes indicate means. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E2 TCR Vβ3, Vβ8, Vβ13.1, and Vβ17 use of T-cell subsets. TCR Vβ chains were determined before (T0), 1 month (T1), or 6 months (T6) after starting VIT. N = 20 (T0 and T1) and n = 9 (T6). Each circle represents 1 patient. Dashes indicate means. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E3 Individual changes in Vβ2 and Vβ5.1 frequency distribution of memory Treg and memory T cells after 1 month of VIT (T1) compared with the start of VIT (T0). Change (Δ) in expression is depicted in 1% intervals. Journal of Allergy and Clinical Immunology  , e3DOI: ( /j.jaci ) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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