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Polymorphisms in the Immunoregulatory Genes are Associated with Hematopoietic Recovery and Increased Susceptibility to Bacterial Infections in Patients.

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Presentation on theme: "Polymorphisms in the Immunoregulatory Genes are Associated with Hematopoietic Recovery and Increased Susceptibility to Bacterial Infections in Patients."— Presentation transcript:

1 Polymorphisms in the Immunoregulatory Genes are Associated with Hematopoietic Recovery and Increased Susceptibility to Bacterial Infections in Patients with Thalassaemia Major Undergoing Matched Related Hematopoietic Stem Cell Transplantation  Shanmugaapriya Sellathamby, Kavitha M. Lakshmi, Marc Busson, Auro Viswabandya, Biju George, Vikram Mathews, Mammen Chandy, Dominique Charron, Rajagopal Krishnamoorthy, Ryad Tamouza, Alok Srivastava  Biology of Blood and Marrow Transplantation  Volume 18, Issue 8, Pages (August 2012) DOI: /j.bbmt Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Cumulative rate of neutrophil recovery with respect to splenectomy. Cumulative rate of neutrophil recovery was faster with a median of 13 days in patients who had undergone splenectomy before transplantation compared to 16 days in those who had not (P < .001). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Cumulative rate of neutrophil recovery with respect to IFN-γ +874 gene polymorphism in recipients. Cumulative rate of neutrophil recovery was faster in recipients with IFN-γ +874 A/A genotype compared to those with IFN-γ +874 T/T +T/A genotypes (P = .010). (PIFN-γ - “P” represents patient or recipient.). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions


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