1. Benefit from Earlier Intervention
-60%
-40%
-20% 0%
Age 70
Age 50
Age 40
Reduction in risk in men with 10% reduction in total cholesterol (10 cohort studies)
Adapted from: Law et al. BMJ 1994;308:367-72

2. Rates of Maintenance of Abstinence
Wks 13–24
Wks 13–52
100
OR=2.47
(95% CI 1.95, 3.15) p<0.0001 80
1.35
OR=
(95% CI 1.07, 1.70) p=0.0126 60
70.6 40
49.8
44.0
37.1 20
N=602
12 wks Varenicline +
N=604
12 wks Varenicline +
12 wks Placebo
N=602
12 wks Varenicline +
N=604
12 wks Varenicline +
12 wks Placebo
Adapted from: Tonstad et al. JAMA 2006;296:64-71

3. Attributable CVD Risk Factors
15152 cases and controls in 262 centres in 52 countries
9 risk factors accounted for 90% of acute MI in men and 94% in women 3
Odds
ratio 2 1 DM BP
Stress
Fr/Veg
Smoking
Obesity
Phys Act.
Alcohol
ApoB/ApoA1 60 40
PAR
(%) 20
-20
PAR=population attributable risks
Adapted from: Yusuf S. Lancet 2004;364(9438):937-52