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13-Hydroxy-linoleic acid induces airway hyperresponsiveness to histamine and methacholine in guinea pigs in vivo  Paul A.J. Henricks, PhDa, Ferdi Engels,

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Presentation on theme: "13-Hydroxy-linoleic acid induces airway hyperresponsiveness to histamine and methacholine in guinea pigs in vivo  Paul A.J. Henricks, PhDa, Ferdi Engels,"— Presentation transcript:

1 13-Hydroxy-linoleic acid induces airway hyperresponsiveness to histamine and methacholine in guinea pigs in vivo  Paul A.J. Henricks, PhDa, Ferdi Engels, PhDa, Henk J. van der Lindea, Johan Garssen, PhDb, Frans P. Nijkamp, PhDa  Journal of Allergy and Clinical Immunology  Volume 96, Issue 1, Pages (July 1995) DOI: /S (95) Copyright © 1995 Mosby, Inc. Terms and Conditions

2 FIG. 1 Histamine-induced changes in pulmonary resistance in 13-HODE–treated and control animals before (open circles) and after (filled circles) aerosol administration (n = 3). Values represent means ± SEM. *p < 0.05, **p < 0.005, and ***p < when compared with values obtained before 13-HODE administration (Student's paired t test). RL, Pulmonary resistance. Journal of Allergy and Clinical Immunology  , 36-43DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

3 FIG. 1 Histamine-induced changes in pulmonary resistance in 13-HODE–treated and control animals before (open circles) and after (filled circles) aerosol administration (n = 3). Values represent means ± SEM. *p < 0.05, **p < 0.005, and ***p < when compared with values obtained before 13-HODE administration (Student's paired t test). RL, Pulmonary resistance. Journal of Allergy and Clinical Immunology  , 36-43DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

4 FIG. 2 Methacholine-induced changes in pulmonary resistance in 13-HODE–treated and control animals before (open circles) and after (filled circles) aerosol administration (n = 6). Values represent means ± SEM. *p < 0.05 when compared with values obtained before 13-HODE administration (Student's paired t test). RL, Pulmonary resistance. Journal of Allergy and Clinical Immunology  , 36-43DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

5 FIG. 2 Methacholine-induced changes in pulmonary resistance in 13-HODE–treated and control animals before (open circles) and after (filled circles) aerosol administration (n = 6). Values represent means ± SEM. *p < 0.05 when compared with values obtained before 13-HODE administration (Student's paired t test). RL, Pulmonary resistance. Journal of Allergy and Clinical Immunology  , 36-43DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

6 FIG. 3 Histamine-induced changes in pulmonary resistance after administration of aerosols containing control (open circles), 0.1 (filled triangles), 1.0 (filled squares), or 10 (filled circles) μmol/L 13-HODE solutions. Results are expressed as percentage of maximal control values obtained before aerosol administrations ± SEM (n = 3). *p < 0.05, **p < when compared with control values (Student's unpaired t test). RL, Pulmonary resistance. Journal of Allergy and Clinical Immunology  , 36-43DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

7 FIG. 4 Typical examples of histologic specimens of upper (A, B) and lower (C, D) parts of lungs from vehicle-treated animals (A and C) and 13-HODE–treated guinea pigs (B and D). Infiltration of inflammatory cells was very limited and did not differ between control and 13-HODE–treated animals. (Hematoxylin-eosin stain; ×150.) Journal of Allergy and Clinical Immunology  , 36-43DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

8 FIG. 4 Typical examples of histologic specimens of upper (A, B) and lower (C, D) parts of lungs from vehicle-treated animals (A and C) and 13-HODE–treated guinea pigs (B and D). Infiltration of inflammatory cells was very limited and did not differ between control and 13-HODE–treated animals. (Hematoxylin-eosin stain; ×150.) Journal of Allergy and Clinical Immunology  , 36-43DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

9 FIG. 4 Typical examples of histologic specimens of upper (A, B) and lower (C, D) parts of lungs from vehicle-treated animals (A and C) and 13-HODE–treated guinea pigs (B and D). Infiltration of inflammatory cells was very limited and did not differ between control and 13-HODE–treated animals. (Hematoxylin-eosin stain; ×150.) Journal of Allergy and Clinical Immunology  , 36-43DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

10 FIG. 4 Typical examples of histologic specimens of upper (A, B) and lower (C, D) parts of lungs from vehicle-treated animals (A and C) and 13-HODE–treated guinea pigs (B and D). Infiltration of inflammatory cells was very limited and did not differ between control and 13-HODE–treated animals. (Hematoxylin-eosin stain; ×150.) Journal of Allergy and Clinical Immunology  , 36-43DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

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