1. Insulitis is reduced in CT-treated RIP-LCMV-GP mice.
Insulitis is reduced in CT-treated RIP-LCMV-GP mice. A: Consecutive pancreas tissue sections obtained from mice receiving isotype-matched control antibody, aCD3 and isotype-matched control antibody (aCD3), aCXCL10 alone, or CT at day 31 after infection were stained for insulin, CD4 T cells (CD4), and CD8 T cells (CD8). Images of two representative islets per group are displayed (original magnification, ×20). B: The degree of insulitis was scored as indicated for more than 100 individual islets from pancreas sections of four mice. C: At the end of the observation time (day 182 after infection), pancreas sections from nondiabetic mice were stained for insulin, CD4, and CD8. Images of two representative islets per group are displayed (original magnification, ×20). Note that, in contrast to aCD3 monotherapy, CT resulted in a permanent block of insulitis.
Stanley Lasch et al. Diabetes 2015;64:
©2015 by American Diabetes Association