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What's on the Horizon in the Management of EGFR-Mutated Lung Cancer?

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Presentation on theme: "What's on the Horizon in the Management of EGFR-Mutated Lung Cancer?"— Presentation transcript:

1 What's on the Horizon in the Management of EGFR-Mutated Lung Cancer?

2 Treatment Options for EGFR Mutation-Positive NSCLC

3 Frontline Metastatic Treatment Options in EGFRm NSCLC

4 TKI + VEGF Inhibition RELAY Trial: Erlotinib +/- Ramucirumab

5 TKI + VEGF Inhibition RELAY Trial - Results

6 Will This Strategy Apply to Osimertinib? Osimertinib + VEGF inhibition

7 TKI + Chemotherapy Gefitinib vs Gefitinib + Chemotherapy

8 TKI + Chemotherapy Results

9 Will This Strategy Apply to Osimertinib? Osimertinib + Chemotherapy

10 Will This Strategy Apply to Osimertinib
Will This Strategy Apply to Osimertinib? Osimertinib + Chemotherapy (cont)

11 Mechanism of Resistance to EGFR TKI MET Amplification

12 Subsequent Line Metastatic Treatment Options in EGFRm NSCLC

13 EGFR/cMET Inhibition Bispecific Antibody: JNJ-372

14 Targeting HER3 ADC: U3-1402

15 Treating Patients With Exon 20 Insertions EGFR/HER2 inhibition: TAK 788

16 Leptomeningeal Disease

17 Diagnostics and Real World Experience

18 2L Therapy in Patients With EGFRm NSCLC

19 Chemo IO Combinations Keynote 189: PD-(L)1 Inhibitor and Osimertinib

20 Immunotherapy in ≥2L EGFRm NSCLC

21 IMpower150 Atezolizumab + Bevacizumab and Chemotherapy

22 Earlier Treatment Options in EGFRm NSCLC

23 EGFR TKIs as Adjuvant Therapy

24 Does a Longer Duration of Therapy Provide Greater Benefits?

25 Upcoming Trials to Watch

26 Complementary Therapy

27 Concluding Remarks

28 Abbreviations

29 Abbreviations (cont)

30 Abbreviations (cont)


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