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Sean R. Lucas, MD, MPH, Thomas A.E. Platts-Mills, MD, PhD 

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Presentation on theme: "Sean R. Lucas, MD, MPH, Thomas A.E. Platts-Mills, MD, PhD "— Presentation transcript:

1 Physical activity and exercise in asthma: Relevance to etiology and treatment 
Sean R. Lucas, MD, MPH, Thomas A.E. Platts-Mills, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 115, Issue 5, Pages (May 2005) DOI: /j.jaci Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Proposed factors influencing the patency of bronchioles. Excess mucus and edema caused by poor mucociliary clearance from decreased epithelial stimulation secondary to decreased activity. Smooth muscle latching and decreased chest wall force from decreased deep inspiration and sigh rate. Collagen deposition from chronic inflammation. Adapted from a slide by R. R. Schellenberg. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Axial chest hyperpolarized helium magnetic resonance scan of a patient with mild asthma before (A) and after (B) exercise, demonstrating acute bronchoconstriction and ventilation defects. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions


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