1. Lecture 9 Slides rh

2. LIPID
CATABOLISM

3. lipid menagerie
phospholipid
triglyceride

4. from McDonalds to Metabolism…
fig17-1

5. from McDonalds to Metabolism…

6. The chylomicron: a lipoprotein
fig17-2

7. mobilization of
glycerol
fig17-4

8. connecting
the FA
to CoA-SH
fig17-5

9. connecting
the FA
to CoA-SH
good
leaving
group
fig17-5

10. fig 19-1

11. Carnitine: Charon* of the matrix!
* you know, the boatman on the River Styx

12. Carnitine: Charon* of the matrix!
* you know, the boatman on the River Styx

13. Transport of acyl-carnitine into the matrix
rate-limiting step for oxidation of FAs
fig17-6

14. oxidation of
fatty acids:
three steps,
one new…
fig17-7

15. b-oxidation:
taking it
two carbons
at a time
fig17-8

20. iterated
metabolic
pathway
fig17-8

23. b-oxidation challenges…
monounsaturated FA
odd-carbon FA

24. b-oxidation challenges…
monounsaturated FA
polyunsaturated FA
odd-carbon FA

25. b-oxidation
of a mono-
unsaturated
fatty acid
fig17-9

26. b-oxidation challenges…
monounsaturated FA
polyunsaturated FA
odd-carbon FA

27. what about
3-carbon
leftovers?
fig17-11

28. what about
3-carbon
leftovers?
fig17-11

29. what about
3-carbon
leftovers?
fig 17-11

30. the coenzyme B12 reaction
box17-2

31. deoxyadenosyl
cobalomin or
coenzyme B12
box17-2

33. box17-2

34. comparison
of FA oxidation
mitochondria
vs.
peroxisomes
catalase
box17-13

35. fatty acid
metabolism
in seeds…
fig17-14

36. enzyme evolution in fatty acid oxidation
one
protein
fig17-15

37. ketone
bodies
fig17-16

38. formation
of ketone
bodies from
Ac-CoA
fig17-18

39. formation of ketone bodies from Ac-CoA
fig17-18

40. formation of ketone bodies from Ac-CoA
fig17-18

41. formation of ketone bodies from Ac-CoA
fig17-18

42. formation of ketone bodies from Ac-CoA
fig17-18

43. metabolism of a ketone body
fig17-19

44. fig17-19

45. fig17-19

46. fig17-19

47. liver synthesis of ketone bodies when TCA activity is low
fig17-20